![]() In adjusted regression models using CRP categories, participants with high CRP (>3 mg/dL) had significantly lower MPV compared with the low CRP group (b = −0.20 standard error 0.09 95% confidence interval −0.38 to −0.01 P = 0.035). In adjusted regression models with CRP as a continuous measure, individuals with high CRP had significantly lower MPV (b = −0.04 standard error 0.01 95% confidence interval −0.06 to −0.01 P = 0.002). ![]() Overall mean CRP in the population was 0.4 mg/dL (standard deviation 0.78). In 16,329 participants, mean MPV was 7.9 fL (standard deviation 0.87). Statistical analyses were performed with Stata MP 15.1. Multivariate ordinary least squares regression analysis was used to predict the association. CRP was analyzed both as a continuous variable and as a categorical variable (low, intermediate, or high). We undertook a population study with the National Health and Nutrition Examination Survey (NHANES) data (2005-2010) to investigate the relationship between CRP and MPV. ![]() Studies on the correlation between MPV and CRP have produced ambiguous results. Mean platelet volume (MPV) is a measure of platelet activation, and C-reactive protein (CRP) is an established marker of inflammation. ![]()
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